翻訳と辞書 Words near each other ・ 4-hydroxyglutamate transaminase ・ 4-hydroxymandelate oxidase ・ 4-hydroxymandelate synthase ・ 4-Hydroxymandelic acid ・ 4-hydroxymuconic-semialdehyde dehydrogenase ・ 4-Hydroxynonenal ・ 4-hydroxynonenal-lysine ・ 4-hydroxyphenylacetaldehyde dehydrogenase ・ 4-hydroxyphenylacetaldehyde oxime monooxygenase ・ 4-hydroxyphenylacetate 1-monooxygenase ・ 4-Hydroxyphenylacetate 3-monooxygenase ・ 4-hydroxyphenylacetate decarboxylase ・ 4-Hydroxyphenylacetic acid ・ 4-Hydroxyphenylacetone ・ 4-hydroxyphenylpyruvate decarboxylase ・ 4-Hydroxyphenylpyruvate dioxygenase ・ 4-hydroxyphenylpyruvate dioxygenase inhibitor ・ 4-hydroxyphenylpyruvate oxidase ・ 4-Hydroxyphenylpyruvic acid ・ 4-hydroxyproline epimerase ・ 4-hydroxyquinoline 3-monooxygenase ・ 4-Hydroxytestosterone ・ 4-hydroxythreonine-4-phosphate dehydrogenase ・ 4-Iodo-N,N-dimethylaniline ・ 4-Iodopropofol ・ 4-Koma Nano Ace ・ 4-Maleylacetoacetic acid ・ 4-manifold ・ 4-MBC ・ 4-Me-αMT Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 4-Hydroxyphenylpyruvate dioxygenase ： ウィキペディア英語版 4-Hydroxyphenylpyruvate dioxygenase 4- Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate. HPPD is an enzyme that is found in nearly all aerobic forms of life. The reaction that HPPD achieves is shown here ==Enzyme Mechanism== HPPD is categorized within a class of oxygenase enzymes that usually utilize α-ketoglutarate and diatomic oxygen to oxygenate or oxidize a target molecule.〔Hausinger, Robert (2004). "Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes." Critical Reviews in Biochemistry and Molecular Biology. 39(1) 21-68. http://informahealthcare.com/doi/abs/10.1080/10409230490440541〕 However, HPPD differs from most molecules in this class due to the fact that it does not use α-ketoglutarate, and it only utilizes two substrates while adding both atoms of diatomic oxygen into the product, homogentisate.〔Moran GR. (4-Hydroxyphenylpyruvate dioxygenase ) Arch Biochem Biophys. 2005 Jan 1;433(1):117-28. PMID 15581571〕 The HPPD reaction occurs through a NIH shift and involves the oxidative decarboxylation of an α-oxo acid as well as aromatic ring hydroxylation. The NIH-shift, which has been demonstrated through isotope-labeling studies, involves migration of an alkyl group to form a more stable carbocation. The shift, accounts for the observation that C3 is bonded to C4 in 4-hydroxyphenylpyruvate but to C5 in homogentisate. The predicted mechanism of HPPD can be seen in the following figure 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「4-Hydroxyphenylpyruvate dioxygenase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.